receptor-interacting protein (RIP)

By Targets:	RIP kinase (15) Apoptosis (1) Estrogen Receptor/ERR (2) LRRK2 (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (1)

Targets Recommended: RIP kinase MNK PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114349

HS-1371 1 Publications Verification	RIP kinase	Cardiovascular Disease Cancer
HS-1371 is a potent and ATP-competitive **receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC₅₀** of 20.8 nM .

HY-104021

GSK840 1 Publications Verification GSK'840	RIP kinase	Inflammation/Immunology
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 0.9 nM, and inhibits kinase activity with an IC₅₀ of 0.3 nM .

HY-101032

RIPA-56 4 Publications Verification	RIP kinase	Inflammation/Immunology
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC₅₀ of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome .

HY-125402

GSK-843 3 Publications Verification GSK'843	RIP kinase Apoptosis	Inflammation/Immunology
GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 8.6 nM, and inhibits kinase activity with an IC₅₀ of 6.5 nM. GSK-843 can be used for the research of inflammation .

HY-114492A

(Rac)-GSK547	RIP kinase	Cancer
(Rac)-GSK547 is the racemate of GSK547. GSK547 is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer .

HY-112907

RIP2 Kinase Inhibitor 3	RIP kinase	Inflammation/Immunology
RIP2 Kinase Inhibitor 3 is a highly potent and selective inhibitor of receptor interacting protein-2 (RIP2) Kinase with an IC₅₀ of 1 nM .

HY-19761

RIP2 kinase inhibitor 2 2 Publications Verification	RIP kinase	Cancer
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.

HY-133014

RIP2 kinase inhibitor 1	RIP kinase	Inflammation/Immunology
RIP2 kinase inhibitor 1 (compound 11) is a potent and selective **receptor interacting protein 2 (RIP2) kinase inhibitor with an IC₅₀** of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders .

HY-128585

GNE684	RIP kinase	Inflammation/Immunology Cancer
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean K_i ^app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .

HY-153437

RIP1 kinase inhibitor 7	RIP kinase	Cancer
RIP1 kinase inhibitor 7 (compound 41) is a potent **receptor interacting protein 1 kinase (RIP1) Inhibitor with an IC₅₀** of <100 nM for human RIP1. RIP1 kinase inhibitor 7 has an EC₅₀ of 1-100 nM in the cell necrosis assay .

HY-132205

DS45500853	Estrogen Receptor/ERR	Metabolic Disease
DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC₅₀ value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) .

HY-143201

DS20362725	Estrogen Receptor/ERR	Metabolic Disease
DS20362725 is an estrogen-related receptor α (ERRα) agonist. DS20362725 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC₅₀ value of 0.6 μM. DS20362725 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) .

HY-18900

Nec-4

RIP kinase Inflammation/Immunology

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC₅₀ of 2.6 μM, K_i of 0.46 μM.

Nec-4	RIP kinase	Inflammation/Immunology
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 *(RIP1)* inhibitor, with an IC₅₀ of 2.6 μM, K_i of 0.46 μM.

HY-18901

RIPK1-IN-4
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of **receptor interacting protein 1 (RIP1)** kinase and binds to a DLG-out inactive form of RIP1 with an IC₅₀s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase .

HY-19764

GSK2983559 active metabolite 1 Publications Verification	RIP kinase	Cancer
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

HY-112038A

GSK2983559	RIP kinase	Inflammation/Immunology
GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

HY-100131

GSK481	RIP kinase	Inflammation/Immunology
GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC₅₀ of 1.3 nM, which inhibits Ser ¹⁶⁶ phosphorylation in wild-type human RIP1 (IC₅₀=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC₅₀ of 10 nM .

HY-112038

GSK2983559 free acid	RIP kinase	Inflammation/Immunology
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

HY-148353

PF-06455943	LRRK2	Neurological Disease
PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC₅₀ value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD) .

Species:	Human (4) Mouse (1)
Tag:	His (4) Tag Free (1) GST (1)
Source:	P. pastoris (3) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71853

	RIPK3 Protein, Mouse (P.pastoris, His) Ripk3; Rip3; receptor-interacting serine/threonine-protein kinase 3; EC 2.7.11.1; RIP-like protein kinase 3; receptor-interacting protein 3; RIP-3; mRIP3	Mouse	P. pastoris
	RIPK3 Protein, participates in programmed necrosis (necroptosis) and apoptosis, contributing to diverse cellular processes. RIPK3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of RIPK3 Protein, Mouse (P.pastoris, His) is 486 a.a., with molecular weight of ~64 kDa.

HY-P71855

	RIPK3 Protein, Human (P.pastoris, His) receptor interacting protein 3; receptor interacting serine threonine kinase 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3	Human	P. pastoris
	RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. RIPK3 Protein, Human (P.pastoris, His) is the recombinant human-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of RIPK3 Protein, Human (P.pastoris, His) is 518 a.a., with molecular weight of ~64 kDa.

HY-P700624

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

HY-P701767

	RIPK1 Protein, Human (Sf9) RIPK1; receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; receptor-interacting protein 1; RIP-1	Human	Sf9 insect cells
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival. RIPK1 Protein, Human (Sf9) is the recombinant human-derived RIPK1 protein, expressed by Sf9 insect cells , with tag free. The total length of RIPK1 Protein, Human (Sf9) is 327 a.a., .

HY-P701768

	RIPK1 Protein, Human (Sf9, His, GST) RIPK1; receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; receptor-interacting protein 1; RIP-1	Human	Sf9 insect cells
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival. RIPK1 Protein, Human (Sf9, His, GST) is the recombinant human-derived RIPK1 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of RIPK1 Protein, Human (Sf9, His, GST) is 327 a.a., .


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Cat. No.	Product Name	Application	Reactivity

HY-P81539

p-RIPK1(S166) Antibody (YA1284)

Cell death protein RIP,receptor-interacting protein 1
WB, IHC-F, IHC-P, FC, ICC/IF, IP Human, Mouse, Rat

HY-P81224

NR1H4 Antibody Bile Acid receptor NR1H4; BAR; FXR; Farnesoid X activated receptor; Farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR 1; Farnesol receptor HRR-1; Farnesol receptor HRR1; FXR; HRR 1; HRR1; NR1H4_HUMAN; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor interacting protein 14; Retinoid X receptor-interacting protein 14; RIP 14; RIP14; RXR interacting protein 14; RXR-interacting protein 14.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse(predicted: Rat, Dog, Pig, Cow, Horse, Sheep)
NR1H4 Antibody is an unconjugated, approximately 56 kDa, rabbit-derived, anti-NR1H4 polyclonal antibody. NR1H4 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, and predicted: rat, dog, pig, cow, horse, sheep background without labeling.

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